Golden Citations Award
‘Golden Citations Award’ 명예의 전당은 단일 논문의 피인용 횟수 1,000회 이상을 기록하여 세계적으로 영향력 있는 연구 성과를 보여 준 최우수 연구자를 기리기 위해 마련되었습니다.
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천진우 교수 고등과학원/이과대학 화학
닫기논문
- 논문제목Shape control of semiconductor and metal oxide nanocrystals through nonhydrolytic colloidal routes
- 학술지명ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- 게재연도2006년
- SCOPUS 피인용 횟수1,066회(2022. 12. 31. 기준)
- 논문 초록Inorganic nanocrystals with tailored geometries exhibit unique shape-dependent phenomena and subsequent utilization of them as building blocks for the fabrication of nanodevices is of significant interest. Herein, we review the recent developments in the shape control of colloidal nanocrystals with a focus on the scientifically and techno-logically important semiconductor and metal oxide nanocrystals obtained by nonhydrolytic synthetic methods. Many structurally unprecedented motifs have been discovered including polyhedrons, rods and wires, plates and prisms, and other advanced shapes such as branched rods, stars, inorganic dendrites, and dumbbells. The currently proposed shape-guiding mechanisms are presented and the important pioneering studies on the assembly of shape-controlled nanocrystals into ordered superlattices and the fabrication of prototype advanced nanodevices are discussed.
- 논문제목Nanoscale size effect of magnetic nanocrystals and their utilisation for cancer diagnosis via magnetic resonance imaging
- 학술지명JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 게재연도2005년
- SCOPUS 피인용 횟수1,073회(2022. 12. 31. 기준)
- 논문제목Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
- 학술지명NATURE MEDICINE
- 게재연도2007년
- SCOPUS 피인용 횟수1,651회(2022. 12. 31. 기준)
- 논문 초록Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
- 논문제목Exchange-coupled magnetic nanoparticles for efficient heat induction
- 학술지명NATURE NANOTECHNOLOGY
- 게재연도2011년
- SCOPUS 피인용 횟수1,073회(2022. 12. 31. 기준)
- 논문 초록The conversion of electromagnetic energy into heat by nanoparticles has the potential to be a powerful, non-invasive technique for biotechnology applications such as drug release, disease treatment and remote control of single cell functions, but poor conversion efficiencies have hindered practical applications so far. In this Letter, we demonstrate a significant increase in the efficiency of magnetic thermal induction by nanoparticles. We take advantage of the exchange coupling between a magnetically hard core and magnetically soft shell to tune the magnetic properties of the nanoparticle and maximize the specific loss power, which is a gauge of the conversion efficiency. The optimized core-shell magnetic nanoparticles have specific loss power values that are an order of magnitude larger than conventional iron-oxide nanoparticles. We also perform an antitumour study in mice, and find that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.
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임성일 교수 이과대학 물리학
닫기논문
- 논문제목MoS2 nanosheet phototransistors with thickness-modulated optical energy gap
- 학술지명NANO LETTERS
- 게재연도2012년
- SCOPUS 피인용 횟수1,152회(2022. 12. 31. 기준)
- 논문 초록We report on the fabrication of top-gate phototransistors based on a few-layered MoS2 nanosheet with a transparent gate electrode. Our devices with triple MoS2 layers exhibited excellent photodetection capabilities for red light, while those with single- and double-layers turned out to be quite useful for green light detection. The varied functionalities are attributed to energy gap modulation by the number of MoS2 layers. The photoelectric probing on working transistors with the nanosheets demonstrates that single-layer MoS2 has a significant energy bandgap of 1.8 eV, while those of double- and triple-layer MoS2 reduce to 1.65 and 1.35 eV, respectively.
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신인재 교수 이과대학 화학
닫기논문
- 논문제목Recent progress in the development of near-infrared fluorescent probes for bioimaging applications
- 학술지명CHEMICAL SOCIETY REVIEWS
- 게재연도2014년
- SCOPUS 피인용 횟수1,366회(2022. 12. 31. 기준)
- 논문 초록Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon penetration in tissue, minimizes photo-damage to biological samples, and produces low background auto-fluorescence from biomolecules present in living systems. The number of new analyte-responsive NIR fluorescent probes has increased substantially in recent years as a consequence of intense research efforts. In this tutorial review, we highlight recent advances (2010-2013) made in the development and applications of NIR fluorescent probes. The review focuses on NIR fluorescent probes that have been devised to sense various biologically important species, including ROS/RNS, metal ions, anions, enzymes and other related species, as well as intracellular pH changes. The basic principles involved in the design of functional NIR fluorescent probes and suggestions about how to expand applications of NIR imaging agents are also described.
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태진성 교수 이과대학 화학
닫기논문
- 논문제목A rhodamine-based fluorescent and colorimetric chemodosimeter for the rapid detection of Hg2+ ions in aqueous media
- 학술지명JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- 게재연도2005년
- SCOPUS 피인용 횟수1,003회(2022. 12. 31. 기준)
- 논문 초록A rhodamine-based fluorescent and colorimetric chemodosimeter for the rapid detection of Hg2+ ions in aqueous media was developed. The system, which utilizes an irreversible Hg2+-promoted oxadiazole forming reaction, responds instantaneously at room temperature in a 1:1 stoichiometric manner to the amount of Hg2+. The selectivity of this system for Hg2+ over other metal ions is remarkably high, and its sensitivity is below 2 ppb in aqueous solutions.
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강문기 교수 공과대학 전기전자공학
닫기논문
- 논문제목Super-resolution image reconstruction: A technical overview
- 학술지명IEEE SIGNAL PROCESSING MAGAZINE
- 게재연도2003년
- SCOPUS 피인용 횟수2,693회(2022. 12. 31. 기준)
- 논문 초록A new approach toward increasing spatial resolution is required to overcome the limitations of the sensors and optics manufacturing technology. One promising approach is to use signal processing techniques to obtain a high-resolution (HR) image from observed multiple low-resolution (LR) images. Such a resolution enhancement approach has been one of the most active research areas, and it is suggested to call super resolution (SR) image reconstruction. In this article, we use the term "SR image reconstruction" to refer to a signal processing approach toward resolution enhancement because the term "super" in "super resolution" represents very well the characteristics of the technique overcoming the inherent resolution limitation of LR imaging systems. The SR image reconstruction is proved to be useful in many practical cases where multiple frames of the same scene can be obtained, including medical imaging, satellite imaging, and video applications. The goal of this article is to introduce the concept of SR algorithms to readers who are not familiar with this area and to provide insight for experts. For this purpose, we present a technical overview of the various existing SR methodologies which are often employed.
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박철민 교수 공과대학 신소재공학과
닫기논문
- 논문제목Enabling nanotechnology with self assembled block copolymer patterns
- 학술지명POLYMER
- 게재연도2003년
- SCOPUS 피인용 횟수1,382회(2022. 12. 31. 기준)
- 논문 초록Block copolymers (BCPs) have received great attention for the past 40 years but only within the past decade have they been seriously considered for nanotechnological applications. Their applicability to nanotechnology stems from the scale of the microdomains and the convenient tunability of size, shape, and periodicity afforded by changing their molecular parameters. The use of the tensorial physical properties of BCPs in such areas as transport, mechanical, electrical, and optical properties will provide substantial benefits in the future. In this review article, we first focus on the current efforts to utilize BCPs in nanotechnologies including nanostructured membranes, BCP templates for nanoparticle synthesis, photonic crystals, and high-density information storage media. In order to realize these applications, control over microdomain spatial and orientational order is paramount. This article reviews various methods to control BCP microdomain structures in the bulk state as well as in thin films. A variety of biases such as mechanical flow fields, electric fields, temperature gradients, and surface interactions can manipulate the microstructures of BCPs. A particular emphasis is made on two approaches, epitaxy and graphoepitaxy, and their combinations. Manipulation of BCP microdomain structures employing multiple external fields promises realization of many potential nanotechnological applications.
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허용민 교수 의과대학 영상의학교실
닫기논문
- 논문제목Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
- 학술지명NATURE MEDICINE
- 게재연도2007년
- SCOPUS 피인용 횟수1,651회(2022. 12. 31. 기준)
- 논문 초록Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
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박해정 교수 의과대학 핵의학교실
닫기논문
- 논문제목Structural and Functional Brain Networks: From Connections to Cognition
- 학술지명SCIENCE
- 게재연도2013년
- SCOPUS 피인용 횟수1,087회(2022. 12. 31. 기준)
- 논문 초록How rich functionality emerges from the invariant structural architecture of the brain remains a major mystery in neuroscience. Recent applications of network theory and theoretical neuroscience to large-scale brain networks have started to dissolve this mystery. Network analyses suggest that hierarchical modular brain networks are particularly suited to facilitate local (segregated) neuronal operations and the global integration of segregated functions. Although functional networks are constrained by structural connections, context-sensitive integration during cognition tasks necessarily entails a divergence between structural and functional networks. This degenerate (many-to-one) function-structure mapping is crucial for understanding the nature of brain networks. The emergence of dynamic functional networks from static structural connections calls for a formal (computational) approach to neuronal information processing that may resolve this dialectic between structure and function.
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용동은 교수 의과대학 진단검사의학교실
닫기논문
- 논문제목Characterization of a New Metallo-beta-Lactamase Gene, bla(NDM-1), and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India
- 학술지명ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- 게재연도2009년
- SCOPUS 피인용 횟수1,858회(2022. 12. 31. 기준)
- 논문 초록A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex. The isolate, Klebsiella pneumoniae 05-506, was shown to possess a metallo-β-lactamase (MBL) but was negative for previously known MBL genes. Gene libraries and amplification of class 1 integrons revealed three resistance-conferring regions; the first contained blaCMY-4 flanked by ISEcP1 and blc. The second region of 4.8 kb contained a complex class 1 integron with the gene cassettes arr-2, a new erythromycin esterase gene; ereC; aadA1; and cmlA7. An intact ISCR1 element was shown to be downstream from the qac/sul genes. The third region consisted of a new MBL gene, designated blaNDM-1, flanked on one side by K. pneumoniae DNA and a truncated IS26 element on its other side. The last two regions lie adjacent to one another, and all three regions are found on a 180-kb region that is easily transferable to recipient strains and that confers resistance to all antibiotics except fluoroquinolones and colistin. NDM-1 shares very little identity with other MBLs, with the most similar MBLs being VIM-1/VIM-2, with which it has only 32.4% identity. As well as possessing unique residues near the active site, NDM-1 also has an additional insert between positions 162 and 166 not present in other MBLs. NDM-1 has a molecular mass of 28 kDa, is monomeric, and can hydrolyze all β-lactams except aztreonam. Compared to VIM-2, NDM-1 displays tighter binding to most cephalosporins, in particular, cefuroxime, cefotaxime, and cephalothin (cefalotin), and also to the penicillins. NDM-1 does not bind to the carbapenems as tightly as IMP-1 or VIM-2 and turns over the carbapenems at a rate similar to that of VIM-2. In addition to K. pneumoniae 05-506, blaNDM-1 was found on a 140-kb plasmid in an Escherichia coli strain isolated from the patient's feces, inferring the possibility of in vivo conjugation. The broad resistance carried on these plasmids is a further worrying development for India, which already has high levels of antibiotic resistance.
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