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Professor Paik Young-ki

"Distinguished Professor Paik Young-ki Attends the Annual General Meeting for HUPO in Boston"

Korea-led Global Chromosome-Centric Human Proteome Project (C-HPP)

The Korea-led Global Human ChromosomeCentric Human Proteome Project (C-HPP) (Chair: Paik Young-Ki, Underwood Distinguished Prof.) made its official launch on September 10, 2012. As the largest project since the human genome, the C-HPP is planned to be implemented over the next ten years (September 2012-September 2022). The project consortium consists of 25 international teams, which focus on each human chromosome (1-22, X, Y and mitochondria). The headquarters office is located at Yonsei Proteome Research Center, directed by Prof. Paik at Yonsei University. The launching ceremony of the C-HPP was held during the annual congress of the Human Proteome Organization (HUPO) in Boston in 2012, which was attended by officials from the U.S. National Institute of Health, the Canadian Institute of Health Research, and key figures in the fields of biomedical research and bio industries who delivered congratulatory speeches on the vision and significance of the project. Historically, the initial C-HPP team emerged from an exploratory group in Korea that selected chromosome 13 in 2008, while a U.S. team and 22 other teams picked each chromosome according to their interests in 2010- 2012. Thus, Korea initiated and lead this global project. The C-HPP consortium was established in Busan in 2011 by Prof. Paik, chair of this consortium and former president of HUPO (2009-2010), along with his co-chairs, Prof. William S. Hancock at Northeastern University, U.S. (World Class University Prof.), and Prof. György Marko-Varga at Lund University, Sweden. According to recent two publications in Nature Biotechnology (Paik et al., 2012a; Paik & Hancock, 2012b),
the No. 1 journal in biotechnology (impact factor 32.4), the C-HPP aims to identify at least one representative protein encoded by each of the approximately 20,300 human genes. The C-HPP will provide not only potential biomarker candidates for human disease diagnostics but also
a global open Web interface for data collection and presentation of the protein parts list. This will promote new drug development and protein therapeutics for complex diseases such as cancer, cardiovascular disease, and diabetes.
 Yonsei Proteome Research Center(YPRC) is designated at Top 8 Worldwide according to the official government rankings and one of its papers in 2012 was selected among Korea’s Top 5 papers by the survey of BRIC scientists. Further to this, in 2013, the C-HPP consortium housed at YPRC C-HPP published the first special issue of the Journal of Proteome Research (JPR) that was co-edited by Prof. Paik, Prof. Gil Omenn at the University of Michigan, U.S., Prof. Marko-Varga, and Prof. Hancock. Currently, the C-HPP Consortium is recruiting manuscripts for the 2014 JPR special issue to be published in January. Finally, it should be worth noting that the synergistic international collaboration between Profs. Paik and Hancock through the WCU program at Yonsei University was the key to success in the initiation and dissemination of the global human proteome project.

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